Isibulala-zinambuzaneukumelana phakathi kwezinhlobo ze-arthropods ezisakaza izifo ezibalulekile kwezolimo, kwezilwane kanye nezempilo yomphakathi kubangela usongo olukhulu ezinhlelweni zokulawula ama-vector global. Ucwaningo lwangaphambilini lubonise ukuthi ama-arthropod vectors amunca igazi abhekana namazinga aphezulu okufa lapho engenisa igazi eliqukethe ama-inhibitors we-4-hydroxyphenylpyruvate dioxygenase (HPPD), i-enzyme yesibili ku-tyrosine metabolism. Lolu cwaningo luhlole ukusebenza kahle kwe-β-triketone HPPD inhibitors ngokumelene nezinhlobo ezithintekayo nezimelana ne-pyrethroid zezifo ezintathu ezinkulu ezithwala izifo, okuhlanganisa omiyane abasakaza izifo zomlando ezifana nomalaleveva, izifo ezivame ukuvela njengodenga ne-Zika, namagciwane avelayo njenge-Oropuche kanye ne-Usutu virus.
Umehluko phakathi kwezindlela ze-topical, tarsal kanye ne-vial, izindlela zokufaka isicelo, ukulethwa kwezibulala-zinambuzane kanye nobude besikhathi sokusebenza.
Kodwa-ke, naphezu komehluko wokufa phakathi kweNew Orleans neMuheza ngethamo eliphakeme kakhulu, zonke ezinye izigxivizo zazisebenza kakhulu eNew Orleans (kungenwa kalula) kunaseMuheza (ukungazweli) ngaphezu kwamahora angama-24.
Imiphumela yethu ibonisa ukuthi i-nitisinone ibulala omiyane abamunca igazi ngokuthintana ne-transtarsal, kanti i-mesotrione, i-sulfotrione, ne-tepoxiton azibabulali. Le ndlela yokubulala ayikhethi phakathi kwezinhlobo zomiyane ezizwelayo noma ezimelana kakhulu nezinye izigaba zezibulala-zinambuzane, okuhlanganisa i-pyrethroids, i-organochlorines, kanye ngokunokwenzeka nama-carbamates. Ngaphezu kwalokho, ukusebenza kahle kwe-nitisinone ekubulaleni omiyane ngokumuncwa kwe-epidermal akugcini nje ezinhlotsheni ze-Anopheles, njengoba kuboniswa ukusebenza kahle kwayo ngokumelene ne-Strongyloides quinquefasciatus ne-Aedes aegypti. Idatha yethu isekela isidingo socwaningo olwengeziwe ukuze kuthuthukiswe ukumuncwa kwe-nitisinone, okungenzeka ngokuthuthukiswa kwamakhemikhali kokumuncwa kwe-epidermal noma ukungezwa kwama-adjuvant. Ngohlelo lwayo olusha lwesenzo, i-nitisinone isebenzisa ukuziphatha okumunca igazi komiyane besifazane. Lokhu kuyenza ibe yikhandidethi elithembisayo lokusungula izifutho eziyinsalela zasendlini kanye namanetha abulala izinambuzane ahlala isikhathi eside, ikakhulukazi ezifundeni lapho izindlela zendabuko zokulawula omiyane zingasebenzi ngenxa yokuvela ngokushesha kokumelana ne-pyrethroid.
Isikhathi sokuthumela: Aug-06-2025