I-β-Triketone Nitisinone Ibulala Omiyane Abangamelani Nezinambuzane Ngokumunca Isikhumba | Izimuncagazi Nama-Vector

   Isibulala-zinambuzaneUkumelana phakathi kwama-arthropod adlulisa izifo ezibalulekile kwezolimo, ezilwaneni kanye nempilo yomphakathi kusongela kakhulu izinhlelo zokulawula ama-vector emhlabeni jikelele. Izifundo zangaphambilini zibonise ukuthi ama-vectors e-arthropod ancela igazi abhekana namazinga aphezulu okufa lapho edla igazi eliqukethe izithibi ze-4-hydroxyphenylpyruvate dioxygenase (HPPD), i-enzyme yesibili ekusetshenzisweni kwe-tyrosine. Lolu cwaningo luhlole ukusebenza kahle kwama-beta-triketone HPPD inhibitors ngokumelene nezinhlobo ezisengozini kanye nezingamelani ne-pyrethroid zezifo ezintathu ezinkulu, okuhlanganisa omiyane abadlulisela izifo zomlando ezifana nomalaleveva, izifo eziphindaphindayo ezifana ne-dengue kanye ne-Zika, kanye namagciwane avelayo afana namagciwane e-Oropuche kanye ne-Usutu.

Umehluko phakathi kwezindlela zokusebenzisa i-topical, i-tarsal kanye ne-vial, izindlela zokusebenzisa, ukulethwa kwezibulala-zinambuzane kanye nobude besikhathi sokusebenza.
Kodwa-ke, naphezu komehluko wokufa phakathi kweNew Orleans neMuheza ngesilinganiso esiphezulu, wonke amanye amazinga ayesebenza kahle eNew Orleans (athintekayo) kunaseMuheza (amelana nemithi) emahoreni angama-24.
Imiphumela yethu ikhombisa ukuthi i-nitisinone ibulala omiyane abamunca igazi ngokuxhumana kwe-transtarsal, kanti i-mesotrione, i-sulfotrione, ne-tepoxiton ayihlukanisi. Le ndlela yokubulala ayihlukanisi phakathi kwezinhlobo zomiyane ezizwela kakhulu noma ezimelana kakhulu nezinye izinhlobo zezibulala-zinambuzane, okuhlanganisa ama-pyrethroids, ama-organochlorine, kanye nama-carbamates. Ngaphezu kwalokho, ukusebenza kahle kwe-nitisinone ekubulaleni omiyane ngokumunca i-epidermal akugcini nje ezinhlotsheni ze-Anopheles, njengoba kuboniswe ukusebenza kwayo ngokumelene ne-Strongyloides quinquefasciatus kanye ne-Aedes aegypti. Imininingwane yethu isekela isidingo socwaningo olwengeziwe lokuthuthukisa ukumunca kwe-nitisinone, mhlawumbe ngokuthuthukisa amakhemikhali okumunca i-epidermal noma ukwengeza ama-adjuvants. Ngendlela yayo entsha yokusebenza, i-nitisinone isebenzisa ukuziphatha kokumunca igazi komiyane besifazane. Lokhu kuyenza ibe yisinqumo esithembisayo sokufafaza okusele kwangaphakathi okusha kanye namanethi okubulala izinambuzane ahlala isikhathi eside, ikakhulukazi ezindaweni lapho izindlela zokulawula omiyane zendabuko zingasebenzi ngenxa yokuvela okusheshayo kokumelana ne-pyrethroid.