Silinganise amazinga omchamo we-3-phenoxybenzoic acid (3-PBA), i-metabolite ye-pyrethroid, kubantu abadala baseKorea abayi-1239 basemakhaya nasemadolobheni. Siphinde sahlola ukuchayeka kwe-pyrethroid sisebenzisa umthombo wedatha wemibuzo;
Isibulala-zinambuzane sasekhayaizifutho ziwumthombo omkhulu wokuchayeka ezingeni lomphakathi kuma-pyrethroids phakathi kwabantu abadala eNingizimu Korea, okuxwayisa ngesidingo sokulawula okukhulu izici zemvelo ama-pyrethroids avame ukuchayeka kuzo, okuhlanganisa izifutho zezibulala-zinambuzane.
Ngenxa yalezi zizathu, ukufunda ngemiphumela ye-pyrethroids kubantu asebekhulile kungaba yinto ebalulekile eKorea nakwamanye amazwe anenani labantu asebekhulile elikhula ngokushesha. Kodwa-ke, kunenani elilinganiselwe lezifundo eziqhathanisa ukuchayeka kwe-pyrethroid noma amazinga e-3-PBA kubantu abadala ezindaweni zasemakhaya noma zasemadolobheni, futhi zimbalwa izifundo ezibika izindlela ezingaba khona zokuchayeka kanye nemithombo engaba khona yokuchayeka.
Ngakho-ke, silinganise amazinga e-3-PBA kumasampula omchamo wabantu asebekhulile eKorea futhi saqhathanisa amazinga e-3-PBA kumchamo wabantu asebekhulile basemakhaya nasemadolobheni. Ngaphezu kwalokho, sihlole isilinganiso esidlula imikhawulo yamanje ukuze sinqume ukuvezwa kwe-pyrethroid kubantu abadala eKorea. Siphinde sahlola imithombo engaba khona yokuvezwa kwe-pyrethroid sisebenzisa imibuzo futhi sayihlobanisa namazinga e-3-PBA omchamo.
Kulolu cwaningo, silinganise amazinga e-3-PBA yomchamo kubantu abadala baseKorea abahlala ezindaweni zasemakhaya nasemadolobheni futhi sahlola ubudlelwano phakathi kwemithombo engaba khona yokuchayeka kwe-pyrethroid kanye namazinga e-3-PBA yomchamo. Siphinde sanquma isilinganiso sokweqisa kwemingcele ekhona futhi sahlola umehluko phakathi kwabantu ngabanye kanye nangaphakathi kwamazinga e-3-PBA.
Esifundweni esashicilelwe ngaphambilini, sithole ubudlelwano obubalulekile phakathi kwamazinga e-3-PBA yomchamo kanye nokwehla kokusebenza kwamaphaphu kubantu abadala basemadolobheni eNingizimu Korea [3]. Ngenxa yokuthi sithole ukuthi abantu abadala basemadolobheni baseKorea babechayeke emazingeni aphezulu e-pyrethroids esifundweni sethu sangaphambilini [3], siqhathanise njalo amazinga e-3-PBA omchamo wabantu abadala basemakhaya nasemadolobheni ukuze sihlole izinga lamanani e-pyrethroid eqile. Lolu cwaningo lwabe seluhlola imithombo engaba khona yokuchayeka kwe-pyrethroid.
Ucwaningo lwethu lunamandla amaningana. Sisebenzise izilinganiso eziphindaphindwayo ze-3-PBA yomchamo ukuze sibonise ukuvezwa kwe-pyrethroid. Lo mklamo wephaneli ende ungabonisa izinguquko zesikhathi ekuvezweni kwe-pyrethroid, okungashintsha kalula ngokuhamba kwesikhathi. Ngaphezu kwalokho, ngalolu mklamo wocwaningo, singahlola isihloko ngasinye njengokulawula kwaso futhi sihlole imiphumela yesikhashana yokuvezwa kwe-pyrethroid sisebenzisa i-3-PBA njenge-covariate yesikhathi ngaphakathi kwabantu ngabanye. Ngaphezu kwalokho, saba ngabokuqala ukuhlonza imithombo yemvelo (engeyona eyomsebenzi) yokuvezwa kwe-pyrethroid kubantu abadala eKorea. Kodwa-ke, ucwaningo lwethu lunemikhawulo. Kulesi sifundo, siqoqe ulwazi ngokusetshenziswa kwezifutho zokubulala izinambuzane sisebenzisa uhlu lwemibuzo, ngakho-ke isikhathi esiphakathi kokusetshenziswa kwezifutho zokubulala izinambuzane kanye nokuqoqwa komchamo asikwazanga ukunqunywa. Nakuba amaphethini okuziphatha okusetshenziswa kwezifutho zokubulala izinambuzane engashintshi kalula, ngenxa ye-metabolism esheshayo ye-pyrethroid emzimbeni womuntu, isikhathi esiphakathi kokusetshenziswa kwezifutho zokubulala izinambuzane kanye nokuqoqwa komchamo singathinta kakhulu amazinga e-3-PBA yomchamo. Ngaphezu kwalokho, abahlanganyeli bethu babengameleli njengoba sigxile endaweni eyodwa yasemakhaya kanye neyodwa yasemadolobheni, yize amazinga ethu e-3-PBA ayefana nalawo alinganiswa kubantu abadala, kufaka phakathi abantu abadala, ku-KoNEHS. Ngakho-ke, eminye imithombo yemvelo ehlotshaniswa nokuchayeka kwe-pyrethroid kufanele ifundwe kabanzi kubantu abadala asebekhulile.
Ngakho-ke, abantu abadala eKorea babhekene nokwanda okukhulu kwe-pyrethroids, kanti ukusetshenziswa kwezifutho zokubulala izinambuzane kungumthombo oyinhloko wokuchayeka emvelweni. Ngakho-ke, kudingeka ucwaningo olwengeziwe ngemithombo yokuchayeka kwe-pyrethroid kubantu abadala eKorea, futhi kudingeka ukulawulwa okuqinile ezintweni zemvelo ezivame ukuchayeka, okuhlanganisa nokusetshenziswa kwezifutho zokubulala izinambuzane, ukuze kuvikelwe abantu abasengozini yokuthola i-pyrethroids, okuhlanganisa nokuchayeka kumakhemikhali emvelo.
Isikhathi sokuthunyelwe: Septhemba-27-2024