Ukuchayeka kuma-pyrethroids kungase kwenyuse ingozi yesifo sikaParkinson ngenxa yokusebenzelana nezakhi zofuzo ngamasosha omzimba.
Ama-pyrethroids atholakala kwezentengiselwano eziningiizibulala-zinambuzane zasendlini. Nakuba ziyi-neurotoxic ezinambuzaneni, ngokuvamile zibhekwa njengeziphephile ukuthintana nabantu yiziphathimandla zenhlangano.
Izinguquko zofuzo kanye nokuchayeka kwezibulala-zinambuzane kubonakala kuthonya ingozi yesifo sika-Parkinson. Ucwaningo olusha luthola ukuxhumana phakathi kwalezi zici ezimbili eziyingozi, okugqamisa indima yokusabela komzimba ekuqhubekeleni phambili kwesifo.
Okutholakele kuhlobene nekilasi leizibulala-zinambuzaneebizwa ngokuthi ama-pyrethroids, atholakala ezibulala-zinambuzane eziningi zasendlini ezithengiswayo futhi ezisetshenziswa kakhulu kwezolimo njengoba ezinye izibulala-zinambuzane ziqedwa. Nakuba ama-pyrethroids eyi-neurotoxic ezinambuzaneni, iziphathimandla zikahulumeni ngokuvamile zizibheka njengephephile ekuchayekeni kwabantu.
Ucwaningo lungowokuqala ukuxhumanisa ukuchayeka kwe-pyrethroid engozini yofuzo yesifo sika-Parkinson kanye nezigunyazo zokulandelela izifundo, kusho umlobi osesikhundleni esiphezulu uMalu Tansi, Ph.D., uprofesa osizayo we-physiology e-Emory University School of Medicine.
Ukwehluka kofuzo iqembu elikutholile kusendaweni engafaki ikhodi yezakhi zofuzo ze-MHC II (i-histocompatibility complex class II enkulu), iqembu lezakhi zofuzo ezilawula amasosha omzimba.
"Besingalindele ukuthola isixhumanisi esithile se-pyrethroids," kusho uTansey. “Kuyaziwa ukuthi ukuchayeka kakhulu kuma-pyrethroids kungabangela ukungasebenzi kahle kwamasosha omzimba, futhi amangqamuzana asebenza kuwo angatholakala kumangqamuzana omzimba omzimba; Manje sidinga ukuqonda kabanzi mayelana nokuthi ukuchayeka isikhathi eside kuwathinta kanjani amasosha omzimba futhi ngaleyo ndlela kuthuthukisa ukusebenza kwawo.” Ingozi yesifo sikaKinson.”
“Sekunobufakazi obuqinile bokuthi ukuvuvukala kobuchopho noma isimiso somzimba sokuzivikela ezifweni esisebenza ngokweqile singase sibe nomthelela ekuqhubekeleni phambili kwesifo sikaParkinson. "Sicabanga ukuthi okungenzeka lapha ukuthi ukuchayeka kwemvelo kungashintsha impendulo yokuzivikela komzimba kwabanye abantu, kukhuthaze ukuvuvukala okungapheli ebuchosheni."
Kulolu cwaningo, abacwaningi baka-Emory abaholwa u-Tansey kanye no-Jeremy Boss, Ph.D., usihlalo woMnyango WezeMicrobiology kanye Ne-Immunology, bahlanganyele no-Stuart Factor, Ph.D., umqondisi we-Emory's Comprehensive Parkinson's Disease Centre, kanye no-Beate Ritz. , MD, University of California, San Francisco. Ngokubambisana nabacwaningi bezempilo yomphakathi e-UCLA, Ph.D. Umbhali wokuqala walesi sihloko nguGeorge T. Kannarkat, MD.
Abacwaningi be-UCLA basebenzise isizindalwazi sendawo saseCalifornia esihlanganisa iminyaka engama-30 yokusetshenziswa kwezibulala-zinambuzane kwezolimo. Banqume ukuchayeka ngokusekelwe ebangeni (ikheli lomuntu othile nelasekhaya) kodwa abazange balinganise amazinga ezibulala-zinambuzane emzimbeni. Ama-pyrethroids acatshangelwa ukuthi alulaza ngokushesha, ikakhulukazi lapho evezwe elangeni, ngesigamu sempilo enhlabathini yezinsuku kuya kumaviki.
Phakathi kwezihloko ezingu-962 ezivela e-California Central Valley, okuhlukile okujwayelekile kwe-MHC II okuhlanganiswe nokuchayeka okungaphezu kwesilinganiso kwezibulala-zinambuzane zepyrethroid kwandise ingozi yesifo sika-Parkinson. Uhlobo oluyingozi kakhulu lwesakhi sofuzo (abantu abaphethe ama-alleles amabili engozini) lwatholakala kuma-21% eziguli ezine-Parkinson's disease kanye no-16% wezilawuli.
Kuleli qembu, ukuchayeka esakhini sofuzo noma i-pyrethroid kukodwa akuzange kukhulise kakhulu ingozi yesifo sikaParkinson, kodwa inhlanganisela yayenza. Uma kuqhathaniswa nesilinganiso, abantu ababechayeke kuma-pyrethroids futhi ababenengozi enkulu kakhulu yofuzo lwe-MHC II babenengozi ephindwe izikhathi ezingu-2.48 yokuba nesifo sika-Parkinson kunalabo abachayeka kancane futhi babenengozi ephansi kakhulu yofuzo. ingozi. Ukuchayeka kwezinye izinhlobo zezibulala-zinambuzane, njenge-organophosphates noma i-paraquat, akukhulisi ubungozi ngendlela efanayo.
Izifundo ezinkulu zofuzo, okuhlanganisa i-Factor neziguli zakhe, ngaphambilini ziye zaxhumanisa ukuhlukahluka kofuzo lwe-MHC II nesifo sika-Parkinson. Ngokumangazayo, ukwahluka okufanayo kofuzo kuthinta ubungozi besifo sikaParkinson ngendlela ehlukile kubantu baseCaucasus/Europe kanye nabantu baseShayina. Izakhi zofuzo ze-MHC II ziyehluka kakhulu phakathi kwabantu; ngakho-ke, badlala indima ebalulekile ekukhethweni kokufakelwa kwezitho zomzimba.
Okunye ukuhlola kuye kwabonisa ukuthi ukuhlukahluka kofuzo okuhlobene nesifo sikaParkinson kuhlobene nokusebenza kwamangqamuzana omzimba omzimba. Abacwaningi bathola ukuthi phakathi kweziguli ezingu-81 zesifo sikaParkinson kanye nezilawuli zaseYurophu ezivela e-Emory University, amangqamuzana omzimba omzimba avela kubantu abanezingozi eziphakeme zokuhlukahluka kofuzo lwe-MHC II ocwaningweni lwaseCalifornia abonise ama-molecule e-MHC amaningi.
Ama-molecule e-MHC angaphansi kwenqubo “yesethulo se-antigen” futhi angamandla ashayelayo asebenza amaseli e-T futhi abambe wonke amasosha omzimba. Inkulumo ye-MHC II yanda emangqamuzaneni athule eziguli ze-Parkinson kanye nokulawula okunempilo, kodwa impendulo enkulu enseleleni yokuzivikela komzimba ibonakala ezigulini zesifo sikaParkinson ezine-genotypes engozini enkulu;
Ababhali baphethe ngokuthi: “Imininingwane yethu iphakamisa ukuthi ama-biomarker eselula, njengokuvula i-MHC II, angase abe usizo kakhulu kunama-molecule ancibilikayo ku-plasma naku-cerebrospinal fluid ekuhlonzeni abantu abasengozini yesifo noma ngokuqasha iziguli ukuthi zibambe iqhaza ekuhlolweni kwemithi yokuzivikela komzimba.” "Isivivinyo."
Ucwaningo lusekelwe yiNational Institute of Neurological Disorders and Stroke (R01NS072467, 1P50NS071669, F31NS081830), iNational Institute of Environmental Health Sciences (5P01ES016731), iNational Institute of General Medical Sciences (GM47310), i-Sartain Foundation, i-Family Foundation i-Michael J. Foxpa Kingson Foundation for Disease Ucwaningo .
Isikhathi sokuthumela: Jun-04-2024