Ukuchayeka kuma-pyrethroids kungandisa ingozi yesifo sikaParkinson ngenxa yokusebenzisana nezakhi zofuzo ngokusebenzisa isimiso somzimba sokuzivikela.
Ama-pyrethroids atholakala ezindaweni eziningi zokuhwebaizibulala-zinambuzane zasekhayaNakuba zinobuthi ezinambuzaneni, ngokuvamile zibhekwa njengeziphephile ukuthintana nabantu yiziphathimandla zikahulumeni.
Ukwehlukahluka kwezakhi zofuzo kanye nokuchayeka ezibulala-zinambuzane kubonakala kuthonya ingozi yesifo sikaParkinson. Ucwaningo olusha luthola ukuxhumana phakathi kwalezi zici ezimbili eziyingozi, luqokomisa indima yokusabela komzimba ekuqhubekeni kwesifo.
Okutholakele kuhlobene nesigaba se-izibulala-zinambuzaneokubizwa ngokuthi ama-pyrethroids, atholakala ezibulala-zinambuzane eziningi zasekhaya ezithengiswayo futhi asetshenziswa kakhulu kwezolimo njengoba ezinye izibulala-zinambuzane ziqedwa. Nakuba ama-pyrethroids enobuthi ezinzwaneni, iziphathimandla zikahulumeni ngokuvamile ziwabheka ephephile ekuvezweni ngabantu.
Lolu cwaningo lungolokuqala ukuxhumanisa ukuchayeka kwe-pyrethroid nengozi yezakhi zofuzo zesifo sikaParkinson futhi ludinga izifundo ezilandelayo, kusho umbhali ophethe uMalu Tansi, Ph.D., uprofesa osizayo we-physiology e-Emory University School of Medicine.
Uhlobo lwezakhi zofuzo olutholwe yithimba lusesifundeni esingabhalisi ama-gene e-MHC II (major histocompatibility complex class II), iqembu lama-gene alawula isimiso somzimba sokuzivikela.
“Besingalindele ukuthola isixhumanisi esithile kuma-pyrethroids,” kusho uTansey. “Kuyaziwa ukuthi ukuchayeka ngokushesha kuma-pyrethroids kungabangela ukungasebenzi kahle kwamasosha omzimba, futhi ama-molecule asebenza kuwo angatholakala kumaseli omzimba; Manje sidinga ukuqonda kabanzi ngokuthi ukuchayeka isikhathi eside kuthinta kanjani isimiso somzimba sokuzivikela futhi ngaleyo ndlela kuthuthukise ukusebenza kwaso.” Ingozi yesifo sikaKinson.”
"Sekuvele kunobufakazi obuqinile bokuthi ukuvuvukala kobuchopho noma isimiso somzimba sokuzivikela esisebenza ngokweqile singase sibe nomthelela ekuqhubekeni kwesifo sikaParkinson. "Sicabanga ukuthi okungenzeka ukuthi kwenzekani lapha ukuthi ukuchayeka endaweni ezungezile kungashintsha impendulo yomzimba kwabanye abantu, kukhuthaze ukuvuvukala okungapheli ebuchosheni."
Kulolu cwaningo, abacwaningi base-Emory abaholwa nguTansey noJeremy Boss, Ph.D., usihlalo woMnyango weMicrobiology kanye ne-Immunology, basebenzisana noStuart Factor, Ph.D., umqondisi we-Emory's Comprehensive Parkinson's Disease Center, kanye noBeate Ritz., MD, eNyuvesi yaseCalifornia, eSan Francisco. Ngokubambisana nabacwaningi bezempilo yomphakathi e-UCLA, Ph.D. Umbhali wokuqala walesi sihloko nguGeorge T. Kannarkat, MD.
Abacwaningi be-UCLA basebenzise isizindalwazi sendawo saseCalifornia esihlanganisa iminyaka engama-30 yokusetshenziswa kwezibulala-zinambuzane kwezolimo. Banqume ukuchayeka ngokusekelwe ebangeni (emsebenzini womuntu kanye nasemakhaya akhe) kodwa abazange balinganise amazinga ezibulala-zinambuzane emzimbeni. Kucatshangwa ukuthi ama-pyrethroids aphela ngokushesha, ikakhulukazi uma echayeke elangeni, kanti isigamu sempilo yawo enhlabathini sisukela ezinsukwini kuya emavikini.
Phakathi kwabantu abangu-962 abavela eCentral Valley yaseCalifornia, uhlobo oluvamile lwe-MHC II oluhlanganiswe nokuchayeka okungaphezu kwesilinganiso ezibulala-zinambuzane ze-pyrethroid kwandisa ingozi yesifo sikaParkinson. Uhlobo oluyingozi kakhulu lwe-gene (abantu abanezinhlobo ezimbili eziyingozi) lutholakale ku-21% weziguli ezine-Parkinson's disease kanye no-16% wezilawuli.
Kuleli qembu, ukuchayeka ku-gene noma i-pyrethroid kuphela akuzange kwandise kakhulu ingozi yesifo sikaParkinson, kodwa inhlanganisela yenza kanjalo. Uma kuqhathaniswa nesilinganiso, abantu ababechayeke ku-pyrethroid futhi ababenefomu eliyingozi kakhulu le-gene ye-MHC II babenengozi ephindwe izikhathi ezingu-2.48 yokuthola isifo sikaParkinson kunalabo ababechayeke kancane futhi ababenefomu eliyingozi kakhulu le-gene. Ukuchayeka kwezinye izinhlobo zezibulala-zinambuzane, njenge-organophosphates noma i-paraquat, akukhulisi ingozi ngendlela efanayo.
Izifundo ezinkulu zezakhi zofuzo, okuhlanganisa noFactor neziguli zakhe, ziye zaxhumanisa ukuhlukahluka kwezakhi zofuzo ze-MHC II nesifo sikaParkinson. Ngokumangazayo, ukuhlukahluka okufanayo kwezakhi zofuzo kuthinta ingozi yesifo sikaParkinson ngendlela ehlukile kubantu baseCaucasian/baseYurophu kanye nabantu baseShayina. Izakhi zofuzo ze-MHC II ziyahlukahluka kakhulu phakathi kwabantu; ngakho-ke, zidlala indima ebalulekile ekukhetheni ukufakelwa kwezitho zomzimba.
Ezinye izivivinyo zibonise ukuthi ukuhlukahluka kwezakhi zofuzo okuhlobene nesifo sikaParkinson kuhlobene nokusebenza kwamaseli omzimba. Abacwaningi bathole ukuthi phakathi kweziguli ezingu-81 zesifo sikaParkinson kanye nabaqondisi baseYurophu abavela e-Emory University, amaseli omzimba avela kubantu abanezakhi zofuzo ze-MHC II ezisengozini enkulu ezivela ocwaningweni lwaseCalifornia abonise ama-molecule e-MHC engeziwe.
Ama-molecule e-MHC ayisisekelo senqubo "yokwethulwa kwe-antigen" futhi angamandla ashukumisayo avuselela amaseli e-T futhi ahilele lonke uhlelo lokuzivikela komzimba. Ukubonakaliswa kwe-MHC II kuyanda kumaseli athule ezigulini zesifo sikaParkinson kanye nabalawulayo abanempilo, kodwa impendulo enkulu enkingeni yokuzivikela komzimba iyabonakala ezigulini zesifo sikaParkinson ezinezinhlobo zofuzo ezisengozini enkulu;
Abalobi baphetha ngokuthi: “Idatha yethu iphakamisa ukuthi ama-biomarker eseli, njengokusebenza kwe-MHC II, angaba usizo kakhulu kunama-molecule ancibilikayo ku-plasma kanye noketshezi lwe-cerebrospinal ekuboneni abantu abasengozini yesifo noma ekuqasheni iziguli ukuthi zihlanganyele ekuhlolweni kwemithi yokulawula amasosha omzimba.”
Ucwaningo lusekelwe yiNational Institute of Neurological Disorders and Stroke (R01NS072467, 1P50NS071669, F31NS081830), iNational Institute of Environmental Health Sciences (5P01ES016731), iNational Institute of General Medical Sciences (GM47310), iSartain Lanier Family Foundation, kanye neMichael J. Foxpa Kingson Foundation for Disease Research.
Isikhathi sokuthunyelwe: Juni-04-2024