Ukuvela kwesikhashana kokumelana nezibulala-zinambuzane kanye nebhayoloji yezinambuzane ezinkulu ze-malaria, omiyane be-Anopheles, e-Uganda

Ukwandaisibulala-zinambuzaneukumelana kunciphisa ukusebenza kahle kokulawulwa kwe-vector. Ukuqapha ukumelana ne-vector kubalulekile ukuqonda ukuvela kwayo nokuklama izimpendulo ezisebenzayo. Kulolu cwaningo, siqaphe amaphethini okumelana nezinambuzane, i-biology yabantu be-vector, kanye nokwehluka kwezakhi zofuzo okuhlobene nokumelana e-Uganda esikhathini seminyaka emithathu kusukela ngo-2021 kuya ku-2023. E-Mayuga, i-Anopheles funestus ss yayiyinhlobo evelele, kodwa kwakukhona ubufakazi bokuhlanganiswa nezinye izinhlobo ze-An. funestus. Ukutheleleka kwe-Sporozoite kwakuphezulu kakhulu, kwafinyelela ku-20.41% ngoMashi 2022. Ukumelana okunamandla kwabonwa kuma-pyrethroids ngokuphindwe kayishumi ukuhlushwa kokuxilonga, kodwa ukuzwela kwatholakala kancane esivivinyweni se-PBO synergy.
Imephu yezindawo zokuqoqwa komiyane eSifundeni saseMayuge. ISifunda saseMayuge siboniswe ngombala onsundu. Amadolobhana lapho kwaqoqwa khona amakwe ngezinkanyezi eziluhlaza okwesibhakabhaka. Le mephu yadalwa kusetshenziswa isofthiwe yamahhala nevulekile ye-QGIS version 3.38.
Bonke omiyane bagcinwa ngaphansi kwezimo ezijwayelekile zokukhula komiyane: 24–28 °C, umswakama ohlobene ongu-65–85%, kanye nesikhathi semini esijwayelekile esingu-12:12. Izibungu zomiyane zakhuliswa emathileyi ezibungu futhi zondliwa nge-tetramine ngokushesha. Amanzi ezibungu ayeshintshwa njalo ezinsukwini ezintathu kuze kube yilapho zikhula. Abantu abadala abaphumayo bagcinwa emakhejini e-Bugdom futhi bondliwa ngesisombululo sikashukela esingu-10% izinsuku ezingu-3-5 ngaphambi kokuhlolwa kwe-bioassay.
Ukufa ekuhlolweni kwe-bioassay ye-pyrethroid esigabeni se-F1. Ukufa kwamachashazi komiyane be-Anopheles abavezwe kuma-pyrethroid kuphela kanye nama-pyrethroid ngokuhlanganiswa nama-synergists. Amabha amaphutha kubha namashadi ekholomu amelela izikhawu zokuzethemba ezisekelwe ephutheni elijwayelekile le-mean (SEM), kanti i-NA ikhombisa ukuthi ukuhlolwa akwenziwanga. Umugqa ovundlile onamachashazi abomvu umelela izinga lokufa elingu-90% ngaphansi kwalokho ukumelana kuqinisekiswa khona.
Wonke amasethi edatha akhiqizwe noma ahlaziywe phakathi nalolu cwaningo afakiwe esihlokweni esishicilelwe kanye namafayela aso Olwazi Olungeziwe.
Inguqulo yokuqala eku-inthanethi yalesi sihloko ishintshiwe: Inguqulo yokuqala yalesi sihloko ishicilelwe ngephutha ngaphansi kwelayisensi ye-CC BY-NC-ND. Ilayisensi ilungisiwe yaba yi-CC BY.