Isifo sokuphefumula kwezingulube besilokhu siyisifo esiyinkimbinkimbi esihlupha abanikazi bamapulazi ezingulube.I-etiology iyinkimbinkimbi, amagciwane ahlukahlukene, ukusabalala kubanzi, futhi ukuvimbela nokulawula kunzima, okuletha ukulahlekelwa okukhulu emapulazini ezingulube.Eminyakeni yakamuva, izifo zokuphefumula kwepulazi lezingulube zivame ukuletha izifo ezixubile, ngakho-ke sijwayele ukubiza ngokuthi i-pig farm respiratory syndrome.Amagciwane ajwayelekile ahlanganisa iMycoplasma, Haemophilus parasuis, Actinobacillus pleuropneumoniae, indlebe eluhlaza okwesibhakabhaka, i-circovirus kanye nomkhuhlane wezingulube.
Ukuvimbela nokwelashwa kwezifo zokuphefumula, i-tilmicosin inomphumela omuhle
Amagciwane okuphefumula ezingulubeni ahlukaniswe ikakhulukazi amabhaktheriya, amagciwane kanye ne-mycoplasma.Nge-mycoplasma kanye ne-porcine infectious pleuropneumonia, ama-antibiotic avamile amanje athuthukile ukumelana, futhi isizukulwane esisha semithi elwa namagciwane ngokuvamile samukelwa emtholampilo ukuvimbela nokwelapha izifo zokuphefumula kwezingulube.Isibonelo, i-tilmicosin, i-doxycycline, i-tyvalomycin, njll, kanye nemithi yendabuko yamaShayina elwa namagciwane, inomthelela omkhulu.Ucwaningo luye lwabonisa ukuthi i-tilmicosin inomphumela we-antiviral ingxenye, futhi inomphumela omuhle ekulawuleni isifo sokuphefumula kwe-porcine esihambisana ne-porcine PRRS.
I-Tilmicosininenqubo ejulile futhi inezinzuzo eziningi zokumboza izendlalelo ezimbili.
Njengoba sonke sazi, i-tilmicosin ingenye yezidakamizwa ezisebenza kahle kakhulu zokulawula izifo zokuphefumula emapulazini ezingulube.Kodwa-ke, imiphumela ye-tilmicosin ehlukahlukene emakethe ayilingani.Kungani lokhu?Singazihlukanisa kanjani?Kuthiwani ngomehluko?Ku-tilmicosin, izinto zokusetshenziswa zicishe zifane, futhi awukho umehluko omkhulu.Ukukhombisa umphumela womkhiqizo, kuncike kakhulu enqubweni yawo yokukhiqiza.Enqubweni yokukhiqiza umkhiqizo, ukulwela ukuthola umphumela ongcono womkhiqizo sekuyinsakavukela.ukuthuthukiswa umkhuba.
Ikhwalithi ephezului-tilmicosinkufanele ibe nezici ezine: izingulube zithanda ukudla, ukuvikela isisu, ukubola kwamathumbu kanye nokukhululwa kancane.
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Hlukanisa nokubukeka
1. Izinhlayiya ze-tilmicosin ezingagcotshiwe zihle kakhulu futhi kulula ukuncibilika ekamelweni lokushisa, kuyilapho izinhlayiya ze-tilmicosin eziboshwe zishubile futhi kunzima ukuzincibilika ekamelweni lokushisa.
2. I-tilmicosin enhle (njenge-Chuankexin ehuqwe ngama-microcapsules anezingqimba ezimbili) inezinhlayiya ezifanayo neziyindilinga.Ngokuvamile, izinhlayiya ze-tilmicosin eziboshwe ziyahlukahluka ngobukhulu nokufana.
Hlukanisa nokunambitheka emlonyeni (ukunambitheka okuhle)
I-Tilmicosininambitha okubabayo, futhi i-tilmicosin engagcotshiwe ayifanele ukuphathwa ngomlomo.I-Tilmicosin enokunambitheka okubabayo emlonyeni ayigcini nje ngokufinyelela ukuhlushwa kwezidakamizwa ezingafuneki, kodwa futhi ithinta kakhulu ukudla kwezingulube futhi ibangele umonakalo omkhulu.Ukumosha izidakamizwa.
Hlukanisa nokuncibilika kwesisu nokuncibilika kwe-enteric
1. Ukufakwa kwe-tilmicosin kuhlukaniswe kwaba yi-enteric (emelana ne-asidi kodwa engamelani ne-alkali) kanye ne-gastric-soluble (hhayi ukumelana ne-asidi ne-alkali).I-gastric-soluble (engamelani ne-asidi ne-alkali) ehlanganiswe ne-tilmicosin izoncibilika futhi ikhishwe yi-gastric acid esiswini, futhi lapho umuthi ukhishwa, uzogqugquzela i-gastric mucosa ukukhipha ijusi yesisu, futhi ijusi yesisu ngokweqile ingabangela kalula ukopha kwesisu kanye nezilonda zesisu.Uma umuthi uhlakazwa esiswini futhi ukhululwe kusengaphambili, i-bioavailability yomuthi nayo izoncishiswa kakhulu.Ngokuvamile, ukusebenza kahle komuthi oncibilikisiwe esiswini kuzoncishiswa ngamaphesenti angaphezu kuka-10 uma kuqhathaniswa nalawo emathunjini.Lokhu kwandisa kakhulu izindleko zemithi.
2. I-Enteric coating (i-anti-acid kodwa hhayi i-anti-alkali) I-coating ingancibilika futhi ikhishwe nge-gastric acid imvelo engancibiliki endaweni ye-alkaline yamathumbu, ukuvimbela imiphumela emibi ehlukahlukene kanye nokusabela kwe-cardiotoxic okubangelwa ukukhululwa ngaphambi kwesikhathi esiswini.Ngesikhathi esifanayo, i-bioavailability yomuthi emathunjini iyathuthukiswa.Ukukhululwa okusheshayo emathunjini.
I-Enteric coating isebenzisa izinto ezihlukene zokugqoka kanye nezinqubo, futhi ukusebenza kahle kokukhululwa emathunjini nakho kuhlukile.Ukugqoka okuvamile kuncibilika kancane futhi kukhishwe emgodini wesisu kanye nesisombululo sesisu, esihluke kakhulu kumphumela we-double-layer microcapsule coating, futhi izinga lokumuncwa emathunjini amathumbu liyashesha.
Isikhathi sokuthumela: Mar-17-2022