Umuthi wezilwane osebenzayo u-Colistin Sulfate CAS 1264-72-8

Incazelo Yomkhiqizo

Ikakhulukazi inomphumela oqinile we-antibacterial kuma-bacterium angenayo igram, futhi amagciwane azwelayo ahlanganisa i-Pseudomonas aeruginosa, i-Escherichia coli, i-Enterobacteria, i-Klebsiella, i-Salmonella, i-Shigella, i-Pasteurella ne-Vibrio. I-Proteus, i-Brucella, i-Serratia kanye nawo wonke amagciwane e-Gram-positive ayengazweli kulo mkhiqizo.I-Colistin SulfateIsibulala-magciwane esihamba kancane, indima eyinhloko kulwelwesi lwamaseli ebhaktheriya, lapho uthintana namagciwane azwelayo, ukwakheka kwawo kwamakhemikhali e-amino yamahhala (Yang) kanye ne-phosphate ester yezimpande ze-phosphoric acid kulwelwesi lwamaseli webhaktheriya (nge-electronegative), kukhulisa ukungeneka kolwelwesi. , okwenza iseli lezinto ezibalulekile ezifana nama-amino acid, izingoma ze-Piao, i-pyrimidine, i-K + yayo.

Aisicelo

Isetshenziselwa kakhulu ukwelapha izifo zamathumbu ezibangelwa i-Grame-negative bacilli (Escherichia coli, njll.). Iphinde isebenze ngokumelene ne-Pseudomonas aeruginosa (i-sepsis, ukutheleleka komgudu womchamo, ukusha noma ukutheleleka kwenxeba elibuhlungu).

Izici

(1) Inokumelana okuqinile ne-Gram negative bacteria. Ikakhulukazi, inomphumela othize ovimbelayo ekuthuthukisweni ku-Escherichia coli, i-Salmonella, ne-Pseudomonas aeruginosa.

(2) Inomphumela obulala amagciwane. Ngokuvimbela umsebenzi okhethiwe wokungena kwe-cell membrane, amabhaktheriya ayafa.

(3) Cishe azikho izinkinga ngokumelana nezidakamizwa. Akukho ukumelana ne-R-factor okutholakele.

(4) Isebenza ngokubambisana nezidakamizwa ze-anti Gram positive bacteria. Uma kuhlanganiswe ne-zinc bacitracin, i-flavomycin, i-sulfonamides, i-semisynthetic penicillin, i-gentamicin, njll., umphumela uba ngcono nakakhulu.

(5) Akukho okusele. Uma iphathwa ngomlomo, cishe ayidonswa amathumbu, kodwa ngesikhathi sokujova nge-intramuscular, ukuqoqwa kwegazi nokumuncwa kuhle, ngakho-ke asikho isidingo sokukhathazeka mayelana nezinsalela emikhiqizweni yezilwane.

(6) Ukukhuthaza ukukhula kwemfuyo nezinkukhu, futhi kuvimbele futhi kulawuleke izifo ezithathelwanayo emfuyweni nasezinkukhuni.