Ukuchayeka kwamanye amakhemikhali ezinambuzane, njengezibulala-zinambuzane, kuhlotshaniswa nemiphumela emibi yezempilo, ngokusho kokuhlaziywa kwedatha yocwaningo lwenhlangano.
Phakathi kwabahlanganyeli ku-National Health and Nutrition Examination Survey (NHANES), amazinga aphezulu okuchayeka ezibulala-zinambuzane zasendlini ezisetshenziswa ngokuvamile ahlotshaniswa nengozi ephindwe kathathu yokufa kwesifo senhliziyo (ingozi isilinganiso 3.00, 95% CI 1.02–8.80) uDkt. Wei U-Bao kanye nozakwabo baseNyuvesi yase-Iowa e-Iowa City bayabika.
Abantu abasezindaweni eziphakeme kakhulu zokuchayeka kulezi zibulala-zinambuzane nabo babe nengozi engamaphesenti angu-56 yokufa kuzo zonke izimbangela uma kuqhathaniswa nabantu abasezindaweni eziphansi zokuchayeka kulezi zibulala-zinambuzane (RR 1.56, 95% CI 1.08–2. 26).
Kodwa-ke, abalobi baqaphele ukuthi ama-insecticide e-pyrethroid awahlotshaniswa nokufa komdlavuza (RR 0.91, 95% CI 0.31-2.72).
Amamodeli alungiselwe uhlanga/ubuhlanga, ubulili, ubudala, i-BMI, i-creatinine, ukudla, indlela yokuphila, nezici ze-sociodemographic.
Ama-insecticide e-pyrethroid agunyazwe ukuthi asetshenziswe yi-US Environmental Protection Agency futhi avame ukusetshenziswa kakhulu ezintweni ezixosha omiyane, ezixosha izintwala zekhanda, ama-shampoos ezilwane ezifuywayo kanye nezifutho, neminye imikhiqizo yokulawula izinambuzane yasendlini nangaphandle futhi ibhekwa njengephephile uma kuqhathaniswa.
“Nakuba sekukhiqizwe ama-pyrethroids angaphezu kuka-1,000, cishe kuneshumi nambili kuphela izibulala-zinambuzane ze-pyrethroid emakethe yaseMelika, njenge-permethrin, i-cypermethrin, i-deltamethrin ne-cyfluthrin,” kuchaza ithimba lika-Bao, lengeza ngokuthi ukusetshenziswa kwe-pyrethroids “kwandile.”“Emashumini eminyaka amuva nje, isimo siye saba sibi kakhulu ngenxa yokuyekwa kancane kancane kokusetshenziswa kwama-organophosphates ezakhiweni ezihlala abantu.“
Enkulumweni ehambisana nalesi sihloko, uStephen Stellman, Ph.D., MPH, noJean Mager Stellman, Ph.D., waseColumbia University eNew York, baphawula ukuthi ama-pyrethroids “angeyesibili isibulala-zinambuzane esisetshenziswa kakhulu emhlabeni, esenza ingqikithi yezinkulungwane zezilwane. amakhilogremu namashumi ezigidi eziyizinkulungwane zamadola aseMelika.”Ukuthengiswa kwe-US ngamadola aseMelika.“
Ngaphezu kwalokho, “izibulala-zinambuzane ze-pyrethroid zitholakala yonke indawo futhi ukuchayeka akunakugwenywa,” babhala.Akuyona nje inkinga kubasebenzi basemapulazini: “Ukufafaza omiyane basemoyeni ukuze kulawuleke igciwane laseWest Nile kanye nezinye izifo ezithwalwa yizilwane eNew York nakwezinye izindawo kuncike kakhulu kuma-pyrethroids,” kuphawula uStelmans.
Ucwaningo luhlole imiphumela yabantu abadala abangaphezu kuka-2,000 ababambiqhaza kuphrojekthi ye-NHANES ka-1999-2000 abahlolwa ngokomzimba, baqoqa amasampula egazi, futhi baphendula imibuzo yocwaningo.Ukuchayeka kwe-pyrethroid kukalwa ngamazinga womchamo we-3-phenoxybenzoic acid, i-pyrethroid metabolite, futhi ababambiqhaza bahlukaniswa baba yizindawo zokuchayeka.
Phakathi nokulandelwa okulinganiselwe kweminyaka engu-14, abahlanganyeli be-246 bafa: abangu-52 bebulawa umdlavuza kanye nabangu-41 besifo senhliziyo.
Ngokwesilinganiso, abamnyama abangewona ama-Hispanic bavezwe kakhulu kuma-pyrethroids kunama-Hispanics nabamhlophe abangewona ama-Hispanic.Abantu abahola kancane, amazinga aphansi emfundo, kanye nekhwalithi yokudla ephansi nabo bavame ukuba nokuchayeka okuphezulu kakhulu kwe-pyrethroids.
UStellman noStellman bagqamise "impilo emfushane kakhulu" yama-pyrethroid biomarker, isilinganiso samahora angu-5.7 kuphela.
"Ukuba khona kwamazinga atholakalayo ama-metabolite e-pyrethroid aqedwa ngokushesha kubantu abaningi, abahlukahlukene ngokwezindawo kukhombisa ukuchayeka isikhathi eside futhi kwenza kubaluleke ukuhlonza imithombo ethile yemvelo," baphawula.
Kodwa-ke, baphinde baphawula ukuthi ngenxa yokuthi ababambiqhaza bocwaningo babebancane ngeminyaka (iminyaka engu-20 kuye kwengama-59), kunzima ukulinganisa ngokugcwele ubukhulu bokuhlangana nokufa kwenhliziyo.
Kodwa-ke, "i-quotient yengozi ephezulu ngokungavamile" idinga ucwaningo olwengeziwe kulawa makhemikhali kanye nobungozi bawo bezempilo bomphakathi obungaba khona, kusho uStellman noStellman.
Omunye umkhawulo wocwaningo, ngokusho kwababhali, ukusetshenziswa kwamasampula omchamo wensimu ukukala ama-metabolites e-pyrethroid, okungenzeka angabonakali izinguquko ngokuhamba kwesikhathi, okuholela ekuhlukanisweni okungalungile kokuchayeka okujwayelekile kuma-pyrethroid pesticides.
UKristen Monaco ungumbhali ophezulu onguchwepheshe wezindaba ze-endocrinology, Psychiatry kanye ne-nephrology.Uzinze ehhovisi laseNew York futhi ube nenkampani kusukela ngo-2015.
Ucwaningo lusekelwe yiNational Institutes of Health (NIH) nge-University of Iowa Environmental Health Research Centre.
Isikhathi sokuthumela: Sep-26-2023