I-Florfenicoliyi-monofluoro derivative yokwenziwa ye-thiamphenicol, ifomula yama-molecule yi-C12H14Cl2FNO4S, i-crystalline powder emhlophe noma engeyona emhlophe, ayinaphunga, incibilika kancane emanzini kanye ne-chloroform, incibilika kancane ku-glacial acetic acid, incibilika ku-Methanol, i-ethanol. Iyi-antibiotic entsha ye-chloramphenicol ebanzi yokusetshenziswa kwezilwane, eyathuthukiswa ngempumelelo ngasekupheleni kwawo-1980.
Yaqala ukuthengiswa eJapane ngo-1990. Ngo-1993, iNorway yagunyaza umuthi wokwelapha i-furuncle ye-salmon. Ngo-1995, iFrance, i-United Kingdom, i-Austria, iMexico kanye neSpain bagunyaza umuthi wokwelapha izifo zamagciwane okuphefumula ezinkomeni. Uphinde wagunyazwa ukusetshenziswa njengesithasiselo sokudla kwezingulube eJapan naseMexico ukuvimbela nokwelapha izifo zamagciwane ezingulubeni, kanti iChina manje isiwugunyazile umuthi.
Kungumuthi wama-antibiotic, okhiqiza umphumela we-bacteriostatic we-spectrum ebanzi ngokuvimbela umsebenzi we-peptidyltransferase, futhi une-spectrum ebanzi yama-antibacterial, kufaka phakathi ahlukahlukeneI-Gram-positivekanye namagciwane amabi kanye ne-mycoplasma. Amagciwane azwelayo afaka phakathi i-bovine kanye ne-porcine Haemophilus,I-Shigella dysenteriae, I-Salmonella, i-Escherichia coli, i-Pneumococcus, i-Influenza bacillus, i-Streptococcus, i-Staphylococcus aureus, i-Chlamydia, i-Leptospira, i-Rickettsia, njll. Lo mkhiqizo ungasakazeka ungene kumaseli ebhaktheriya ngokuncibilika kwamafutha, usebenza kakhulu kwi-subunit yama-50s ye-ribosome yamabhaktheriya yama-70s, uvimbela i-transpeptidase, uvimbela ukukhula kwe-peptidase, uvimbela ukwakheka kwamaketanga e-peptide, ngaleyo ndlela uvimbele ukwakheka kwamaprotheni, ufeze injongo ye-Antibacterial. Lo mkhiqizo umuncwa ngokushesha ngokuphathwa ngomlomo, usakazeke kabanzi, unesigamu sempilo eside, ukuhlushwa okuphezulu kwemithi yegazi, kanye nesikhathi eside sokugcinwa kwemithi yegazi.
Eminyakeni yamuva nje, amapulazi amaningi amancane naphakathi asebenzise i-florfenicol ekwelapheni kungakhathaliseki ukuthi izingulube zinjani, futhi asebenzise i-florfenicol njengomuthi womlingo. Eqinisweni, lokhu kuyingozi kakhulu. Kunomphumela omuhle wokwelapha ezifweni zezingulube ezibangelwa amagciwane ane-Gram-positive ne-negative kanye ne-mycoplasma, ikakhulukazi ngemva kokuhlanganiswa kwe-florfenicol ne-doxycycline, umphumela uyathuthuka, futhi uyasebenza ekwelapheni i-porcine thoracic pigeon atrophic rhinitis chain. I-Cocci, njll. inomphumela omuhle wokwelapha.
Kodwa-ke, isizathu sokuthi kungani kuyingozi ukusebenzisa i-florfenicol njalo ukuthi kunemiphumela eminingi emibi ye-florfenicol, futhi ukusetshenziswa isikhathi eside kwe-florfenicol kulimaza kakhulu kunokuhle. Isibonelo, abangane bezingulube akufanele bangazinaki lezi zindawo.
1. Uma kunezifo ezibangelwa amagciwane njenge-pseudorabies, umkhuhlane wezingulube onendandatho yendlebe eluhlaza okwesibhakabhaka epulazini lezingulube, ukusetshenziswa kwe-florfenicol ekwelapheni kuvame ukuba yingxenye yalezi zifo ezibangelwa amagciwane, ngakho-ke uma lezi zifo ezingenhla zithelelekile futhi ziba khona. Uma uthelelekile ngezinye izifo zezingulube, ungayisebenzisi i-florfenicol ekwelapheni, kuzosenza lesi sifo sibe sibi kakhulu.
2. I-Florfenicol izophazamisa uhlelo lwethu lwe-hematopoietic futhi ivimbele ukukhiqizwa kwamangqamuzana egazi abomvu emnkantsheni, ikakhulukazi uma izingulube zethu ezincelisayo zinamalunga abandayo noma avuvukele. Umbala wezinwele zengulube awubonakali kahle, izinwele ezithosiwe, kodwa futhi ubonisa izimpawu ze-anemia, uzokwenza nengulube ingadli isikhathi eside, yakhe ingulube eqinile.
3. I-Florfenicol inobuthi esikhumbeni. Uma i-florfenicol ivame ukusetshenziswa ngesikhathi sokukhulelwa ezinsikazini, amaphuphu azophuma azohluleka.
4. Ukusetshenziswa isikhathi eside kwe-florfenicol kuzobangela ukuphazamiseka kwesisu kanye nesifo sohudo ezingulubeni.
5. Kulula ukubangela ukutheleleka kwesibili, njenge-exudative dermatitis ebangelwa ukutheleleka kwe-staphylococcus ezingulubeni noma ukutheleleka kwesibili kwe-fungal dermatitis.
Ngamafuphi, i-florfenicol akufanele isetshenziswe njengomuthi ojwayelekile. Uma sisebenzisa amanye ama-antibiotic angasebenzi kahle futhi enomqondo oxubile (expel virus), singasebenzisa i-florfenicol kanye ne-doxycycline eceleni. I-acupuncture isetshenziselwa ukwelapha izifo ezingapheli, futhi ayinconywa kwezinye izimo.
Isikhathi sokuthunyelwe: Julayi-14-2022