I-Flofenicoliwukwenziwa kwe-monofluoro esuselwe ku-thiamphenicol, ifomula yamangqamuzana ithi C12H14Cl2FNO4S, i-crystalline powder emhlophe noma emhlophe, ayinaphunga, inyibilika kancane emanzini ne-chloroform, inyibilika kancane ku-glacial acetic acid, encibilika ku-Methanol, i-ethanol.Isibulala-magciwane esisha esine-spectrum esibanzi se-chloramphenicol sokusetshenziswa kwezilwane, esakhiwa ngempumelelo ngasekupheleni kwawo-1980.
Yaqala ukumakethwa eJapane ngo-1990. Ngo-1993, iNorway yagunyaza umuthi wokwelapha i-furuncle ye-salmon.Ngo-1995, iFrance, i-United Kingdom, i-Austria, iMexico neSpain yagunyaza umuthi wokwelapha izifo ezibangelwa amagciwane okuphefumula kwezinkomo.Igunyazwe futhi ukusetshenziswa njengesithako sokuphakela kwezingulube e-Japan nase-Mexico ukuvimbela nokwelapha izifo ezibangelwa amagciwane ezingulubeni, futhi i-China manje isiwuvumile umuthi.
Isidakamizwa esilwa namagciwane, esikhiqiza umphumela obanzi we-bacteriostatic ngokuvimbela umsebenzi we-peptidyltransferase, futhi sine-spectrum ebanzi ye-antibacterial, kuhlanganise nezinhlobonhlobo ezihlukahlukene.I-Gram-positivekanye nama-bacteria angalungile kanye ne-mycoplasma.Amagciwane azwelayo ahlanganisa i-bovine ne-porcine Haemophilus,I-Shigella dysentery, i-Salmonella, i-Escherichia coli, i-Pneumococcus, i-Influenza bacillus, i-Streptococcus, i-Staphylococcus aureus, i-Chlamydia, i-Leptospira, i-Rickettsia, njll. Lo mkhiqizo ungasakazekela kumaseli ebhaktheriya ngokusebenzisa ukuncibilika kwe-lipid, ikakhulukazi ku-50sssomeribet, i-rickettsia, i-subunit ye-rickettsia, ukukhula kwe-peptidase, kuvimbela ukwakheka kwamaketanga e-peptide, ngaleyo ndlela kuvimbele ukuhlanganiswa kwamaprotheni, kufezwe injongo ye-Antibacterial.Lo mkhiqizo udonswa ngokushesha ngokuphathwa ngomlomo, usatshalaliswa kabanzi, unohafu wempilo ende, ukugcwala kwezidakamizwa egazini, kanye nesikhathi eside sokugcinwa kwezidakamizwa egazini.
Eminyakeni yamuva nje, amapulazi ezingulube amaningi amancane naphakathi nendawo asebenzise i-florfenicol ukwelashwa kungakhathaliseki isimo sezingulube, futhi asebenzisa i-florfenicol njengesidakamizwa somlingo.Eqinisweni, lokhu kuyingozi kakhulu.Inomphumela omuhle wokwelapha ezifweni zezingulube ezibangelwa amagciwane e-Gram-positive kanye nama-negative kanye ne-mycoplasma, ikakhulukazi ngemva kokuhlanganiswa kwe-florfenicol ne-doxycycline, umphumela uyathuthukiswa, futhi uyasebenza ekwelapheni i-porcine thoracic swine atrophic rhinitis chain.I-Cocci, njll. inomphumela omuhle wokwelapha.
Kodwa-ke, isizathu sokuthi kungani kuyingozi ukusebenzisa i-florfenicol njalo kungenxa yokuthi kunemiphumela emibi eminingi ye-florfenicol, futhi ukusetshenziswa kwesikhathi eside kwe-florfenicol kulimaza kakhulu kunokuhle.Isibonelo, abangani bezingulube akufanele banganaki lamaphuzu.
1. Uma kunezifo ezibangelwa amagciwane ezifana ne-pseudorabies swine fever ene-blue ear ring epulazini lezingulube, ukusetshenziswa kwe-florfenicol ekwelapheni kuvame ukuhambisana nalezi zifo ezibangelwa amagciwane, ngakho-ke uma izifo ezingenhla zithelelekile futhi zilandela ezinye izifo zezingulube, ungasebenzisi i-florfenicol yokwelapha, izokwandisa lesi sifo.
2. I-Flofenicol izophazamisa uhlelo lwethu lwe-hematopoietic futhi ivimbele ukukhiqizwa kwamangqamuzana egazi abomvu emnkantsheni, ikakhulukazi uma izingulube zethu ezincelisayo ziba namalunga abandayo noma avuvukele.Umbala wezinwele zezingulube awubukeki kahle, izinwele ezithosiwe, kodwa futhi ubonisa izimpawu ze-anemia, kuzokwenza futhi ingulube ingadli isikhathi eside, yakha ingulube eqinile.
3. I-Flofenicol ine-embryotoxic.Uma i-florfenicol ivame ukusetshenziswa ngesikhathi sokukhulelwa ezingulubeni, ama-piglets azohluleka.
4. Ukusetshenziswa isikhathi eside kwe-florfenicol kuzodala ukuphazamiseka kwamathumbu kanye nesifo sohudo ezingulubeni.
5. Kulula ukubangela ukutheleleka kwesibili, njenge-exudative dermatitis ebangelwa ukutheleleka kwe-staphylococcus ezingulubeni noma ukutheleleka kwesibili kwesikhunta esithile sesikhunta.
Ukufingqa, i-florfenicol akufanele isetshenziswe njengomuthi ojwayelekile.Uma sisebenzisa amanye ama-antibiotics anomphumela ongemuhle futhi ngomqondo oxubile (khipha igciwane), singasebenzisa i-florfenicol ne-doxycycline eceleni.I-acupuncture isetshenziselwa ukwelapha izifo ezingalapheki, futhi ayinconywa kwezinye izimo.
Isikhathi sokuthumela: Jul-14-2022