I-Flofenicoliyimithi elwa namagciwane ene-spectrum ebanzi, enomphumela omuhle ovimbela amagciwane e-Gram-positive kanye nama-negative bacteria.Ngakho-ke, amapulazi amaningi ezingulube avame ukusebenzisa i-florfenicol ukuvimbela noma ukwelapha izingulube uma kunezifo ezivamile.abagulayo.Izisebenzi zezilwane zamanye amapulazi ezingulube zisebenzisa umthamo omkhulu we-florfenicol ukwelapha noma ukuvimbela izifo kungakhathaliseki ukuthi yisiphi isifo, kungakhathaliseki ukuthi iqembu noma isigaba.I-Flofenicol ayiyona i-panacea, futhi idinga ukusetshenziswa ngokunengqondo ukuze kuzuzwe umphumela oyifunayo.Ngezansi sethula umqondo ojwayelekile wokusetshenziswa kwe-florfenicol ngokuningiliziwe, ngethemba lokuba usizo kuningi labafuyi bezingulube:
1. Izakhiwo zokulwa namagciwane zei-florfenicol
1. Ine-spectrum ye-antibacterial ebanzi kakhulu, futhi inamandla okubulala amagciwane e-Gram-positive kanye nama-bacteria angalungile, kanye namabhaktheriya e-Gram-positive anaerobic kanye nama-spirochetes angalungile, i-rickettsia, i-amoeba, njll. Umphumela onamandla we-antibacterial.
2. Ukuhlolwa kwe-in vitro kanye ne-vivo kubonisa ukuthi umsebenzi wayo wokulwa namagciwane ungcono kakhulu kunemithi elwa namagciwane yamanje.
3. Isebenza ngokushesha, i-florfenicol ingafinyelela ekugxilweni kokwelapha egazini ihora eli-1 ngemuva komjovo we-intramuscular, futhi ukuhlushwa okuphezulu kwezidakamizwa kungafinyelelwa emahoreni angu-1.5-3;Isidakamizwa esisebenza isikhathi eside, esisebenzayo singagcinwa isikhathi esingaphezu kwamahora angu-20 ngemva kokuphathwa okukodwa.
4. Ingangena emgodleni wegazi-ubuchopho, futhi umphumela wayo wokwelapha ku-meningitis yebhaktheriya yezilwane awunakuqhathaniswa nezinye izidakamizwa ezilwa namagciwane.
5. Ayinabo ubuthi nemiphumela engemihle lapho isetshenziswa ngenani elinconyiwe, inqoba ingozi ye-aplastic anemia kanye nobunye ubuthi obubangelwa i-thiamphenicol, futhi ayidali kulimaze izilwane nokudla.Isetshenziselwa ukutheleleka kwezingxenye ezihlukahlukene zomzimba ezibangelwa amagciwane ezilwaneni.Ukwelashwa, okuhlanganisa ukuvimbela nokwelashwa kwezifo zokuphefumula ezibangelwa amagciwane, i-meningitis, i-pleurisy, i-mastitis, izifo zamathumbu kanye nesifo sangemva kokubeletha ezingulubeni.
2. Amagciwane angena kalulai-florfenicol
1. Izifo zezingulube lapho kukhethwa i-florfenicol
Lo mkhiqizo utuswa njengomuthi okhethwayo we-swine pneumonia, porcine infectious pleuropneumonia kanye nesifo se-Haemophilus parasuis, ikakhulukazi ekwelapheni amagciwane amelana ne-fluoroquinolones namanye ama-antibiotic.
2. I-Flofenicol ingasetshenziswa futhi ekwelapheni izifo zezingulube ezilandelayo
Ingase futhi isetshenziselwe ukwelapha izifo zokuphefumula ezibangelwa i-Streptococcus (i-pneumonia), i-Bordetella bronchiseptica (i-atrophic rhinitis), i-Mycoplasma pneumoniae (isifuba somoya wezingulube), njll.;i-salmonellosis (i-piglet paratyphoid), i-colibacillosis (i-piglet asthma) Izifo zohlelo lokugaya ukudla njenge-enteritis ebangelwa uhudo oluphuzi, isifo sohudo esimhlophe, isifo se-piglet edema) namanye amagciwane azwelayo.I-Flofenicol ingasetshenziswa ekwelapheni lezi zifo zezingulube, kodwa akuwona umuthi okhethwayo kulezi zifo zezingulube, ngakho-ke kufanele isetshenziswe ngokuqapha.
3. Ukusetshenziswa ngendlela engafanelei-florfenicol
1. Umthamo mkhulu kakhulu noma mncane kakhulu.Imithamo emikhulu inobuthi, futhi imithamo emincane ayisebenzi..
2. isikhathi side kakhulu.Okunye ukusetshenziswa kwesikhathi eside komthamo omkhulu wezidakamizwa ngaphandle kokuzithiba.
3.ukusetshenziswa kwezinto, amaphutha esiteji.Ingulube ekhulelwe kanye nezingulube ezikhuluphalisayo zisebenzisa izidakamizwa ezinjalo ngokungakhethi, zibangela ubuthi noma izinsalela zezidakamizwa, okuholela ekukhiqizeni okungaphephile nokudla.
4. Ukuhambisana okungalungile.Abanye abantu bavame ukusebenzisa i-florfenicol ngokuhlanganiswa ne-sulfonamides ne-cephalosporins.Ukuthi kungokwesayensi futhi kunengqondo yini kufanelekile ukuhlola.
5. Ukuphakelwa okuxubile akunyakaziswa ngokulinganayo, okubangela kungabikho mphumela wesidakamizwa noma ubuthi bezidakamizwa.
Okwesine, ukusetshenziswa kwei-florfenicolizinyathelo zokuzivikela
1. Lo mkhiqizo akufanele usetshenziswe ngokuhambisana nama-macrolides, i-lincosamide kanye nama-antibiotic e-diterpenoid semi-synthetic - i-Tiamulin, engaveza imiphumela ephikisanayo uma isetshenziswa ngokuhlangene..
2. Lo mkhiqizo awukwazi ukusetshenziswa uhlanganiswe neβ-i-lactone amines kanye ne-fluoroquinolones, ngoba lo mkhiqizo uyi-agent ye-bacteriostatic esebenza ngokushesha evimbela ukuhlanganiswa kwamaprotheni ebhaktheriya, futhi lokhu okulandelayo kuyi-bactericide esebenza ngokushesha ngesikhathi sokuzala.Ngaphansi kwesenzo sangaphambili, i-bacterial protein synthesis ivinjelwa ngokushesha, amabhaktheriya ayeka ukukhula nokuphindaphinda, futhi umphumela we-bactericidal walokhu wokugcina uba buthaka.Ngakho-ke, lapho ukwelashwa kudinga ukwenza umphumela wokuvala inzalo ngokushesha, angeke kusetshenziswe ndawonye.
3. Lo mkhiqizo awukwazi ukuxubaniswa ne-sulfadiazine sodium ngomjovo we-intramuscular.Akufanele isetshenziswe ngokuhambisana nezidakamizwa ezine-alkaline lapho iphathwa ngomlomo noma nge-intramuscularly, ukuze ugweme ukubola nokwehluleka.Ayifanelekile futhi ukujova nge-intravenous nge-tetracycline hydrochloride, kanamycin, adenosine triphosphate, coenzyme A, njll., ukugwema imvula kanye nokuncipha kokusebenza kahle.
4. Ukuwohloka kwemisipha kanye ne-necrosis kungase kubangelwe ngemva komjovo we-intramuscular.Ngakho-ke, ingajovwa ngokushintshana emisipha ejulile yentamo nezinqe, futhi akufanelekile ukuphinda umjovo endaweni efanayo.
5. Njengoba lo mkhiqizo ungase ube ne-embryotoxicity, kufanele usetshenziswe ngokuqapha ezingulubeni ezikhulelwe nezincelisayo.
6. Uma izinga lokushisa lomzimba wezingulube ezigulayo liphakeme, lingasetshenziswa nge-antipyretic analgesics ne-dexamethasone, futhi umphumela ungcono..
7. Ekuvimbeleni nasekwelapheni i-porcine Respiratory Syndrome (PRDC), abanye abantu batusa inhlanganisela ye-florfenicol ne-amoxicillin, i-florfenicol ne-tylosin, ne-florfenicol ne-tylosin, okungafanelekile., ngoba ngokombono we-pharmacological, lezi ezimbili azikwazi ukusetshenziswa ngokuhlanganiswa.Kodwa-ke, i-florfenicol ingasetshenziswa ngokuhambisana ne-tetracyclines njenge-doxycycline..
8. Lo mkhiqizo unobuthi be-hematological.Nakuba ingeke ibangele i-aplastic anemia yomnkantsha engalungiseki, ukuvinjelwa kwe-erythropoiesis ehlehliswayo okubangelwa yikho kuvame kakhulu kune-chloramphenicol (ekhubazekile).I-contraindicated ngesikhathi sokugoma noma izilwane ezine-immunodeficiency enzima..
9. Ukusetshenziswa isikhathi eside kungase kubangele ukuphazamiseka kokugaya ukudla kanye nokuntuleka kwamavithamini noma izimpawu ze-superinfection..
10. Ekuvimbeleni nasekwelapheni izifo zezingulube, ukunakekelwa kufanele kuthathwe, futhi umuthi kufanele uphathwe ngokuhambisana nomthamo onqunyiwe kanye nenkambo yokwelashwa, futhi akufanele isetshenziswe kabi ukuze ugweme imiphumela emibi..
11. Ezilwaneni ezinokwehluleka kwezinso, umthamo kufanele wehliswe noma isikhathi sokuphatha kufanele sinwetshwe..
12. Uma izinga lokushisa liphansi, kutholakala ukuthi izinga lokuchithwa lihamba kancane;noma isixazululo esilungisiwe sinemvula ye-florfenicol, ukushisa okuncane nje (okungadluli ku-45℃), konke kungancibilika ngokushesha.Isixazululo esilungisiwe sisetshenziswa kangcono kungakapheli amahora angama-48..
Kuphephe kakhulu ukusebenzisa ifomu ledosi elifanele ngokwesingeniso esingenhla futhi ubhekisele kumthamo onconyiwe.Izilwane ngazinye zingase zibe nokuphelelwa ukudla kwesikhashana, ukuncishiswa kwamanzi noma isifo sohudo, ubuhlungu obuncane endaweni yomjovo we-intramuscular kanye nokusabela okuncane kwezicubu, okujwayelekile futhi kubuyele kokujwayelekile ngemva kokuyeka umuthi.
Isikhathi sokuthumela: Mar-28-2022