I-Thiostrepton Esezingeni Eliphezulu 99% CAS No 1393-48-2

Isingeniso

I-THIOSTREPTON iyi-antibiotic enamandla etholakala emikhiqizweni yokubilisa yezinhlobo ezithile zebhaktheriya i-Actinomycete. Ingaphansi kwesigaba se-thiopeptide sama-antibiotic futhi ithole ukuqashelwa ngokusebenza kwayo okuphawulekayo ngokumelene namagciwane ahlukahlukene e-Gram-positive, okuhlanganisa i-MRSA (i-methicillin-resistant Staphylococcus aureus).I-Thiostreptoniye yafundwa kabanzi futhi ibonise ithemba ezindleleni ezahlukene zezokwelapha, zezilwane, kanye nezolimo. Ngezici zayo eziyingqayizivele kanye nezakhiwo zayo ezivelele zokulwa namagciwane, iThiostrepton iyaqhubeka nokuguqula insimu yokwelapha ngama-antibiotic.

Izici

1. Amandla:I-ThiostreptonIyaziwa ngamandla ayo amangalisayo okulwa namagciwane amaningi ayingozi kanye nesikhunta. Isebenza ngokuvimbela ngokukhetha ukwakheka kwamaprotheni ebhaktheriya, iqinisekisa isenzo esiqondiwe ngokumelene namagciwane abangela izifo ngenkathi ilondoloza amagciwane anenzuzo.

2. I-Broad Spectrum: I-spectrum yomsebenzi we-Thiostrepton ihlanganisa amabhaktheriya amaningi ane-Gram-positive kanye nezinhlobo ezithile ze-anaerobic. Lokhu kuguquguquka kuvumela ukusetshenziswa okubanzi ezindaweni ezahlukene zezokwelapha, zezilwane, kanye nezolimo.

3. Ukuphepha: I-Thiostrepton inephrofayili yokuphepha enhle kakhulu, okwenza ifaneleke ukusetshenziswa ezinhlotsheni ezahlukahlukene. Ubuthi bayo obuphansi kanye nemiphumela emibi engabaluleki kahle ivumela ukusetshenziswa kwayo ezindaweni ezibucayi, njengeyunithi ye-ICU kanye namapulazi ezilwane.

4. Ukuvimbela Ukumelana: Ngokungafani namanye ama-antibiotic, i-Thiostrepton ibonise ukuthambekela okuphansi kokuthuthukiswa kokumelana namagciwane ngenxa yendlela yayo yokusebenza ehlukile. Lokhu kuyenza ithuluzi elibalulekile ekulweni nenkinga ekhulayo yokumelana namagciwane.

Isicelo

1. Ukunakekelwa Kwempilo Kwabantu: I-Thiostrepton ibonise amandla amakhulu ekusetshenzisweni kwezempilo kwabantu. Ivame ukusetshenziswa ekwelapheni izifo zesikhumba ezifana ne-impetigo, i-dermatitis, kanye ne-cellulitis ebangelwa yi-Staphylococcus aureus kanye ne-Streptococcus pyogenes. Ngaphezu kwalokho, i-Thiostrepton ibonise imiphumela ethembisayo ekwelapheni izifo zokuphefumula, okuhlanganisa i-pneumonia kanye ne-bronchitis. Umsebenzi wayo wokulwa ne-MRSA, uhlobo oludumile olumelana nama-antibiotic, uyenze yaba usizo kakhulu ezibhedlela.

2. Ukwelapha Ngezilwane: I-Thiostrepton isetshenziswe kakhulu kwezokwelapha ngezilwane. Ibhekana nokutheleleka okuhlukahlukene kwamagciwane okuthinta imfuyo, izinkukhu, kanye nezilwane ezihambisana nayo. Ukusebenza kwayo kahle emagciwaneni avamile njenge-Staphylococcus, i-Streptococcus, kanye nezinhlobo ze-Clostridium kube negalelo elikhulu ekuthuthukiseni impilo yezilwane kanye nenhlalakahle yazo. Ngaphezu kwalokho, iphrofayili yokuphepha enhle kakhulu ye-Thiostrepton iyenza ibe ukukhetha okuhle kokwelapha izifo ezilwaneni, inciphise imiphumela emibi engaba khona.

3. Ezolimo: I-Thiostrepton inamandla amakhulu ekusetshenzisweni kwezolimo. Ingalwa namagciwane ezitshalweni njenge-Actinomyces kanye ne-Streptomyces, inciphise ukwanda kwezifo zezitshalo futhi ithuthukise isivuno. I-Thiostrepton ingasetshenziswa njengesifutho samaqabunga noma ekwelapheni imbewu ukuze ivikeleke ekuthelelekeni ngesikhunta kanye namagciwane ezitshalweni ezahlukene. Ngokulawula izifo zezitshalo ngempumelelo, i-Thiostrepton inegalelo kwezolimo ezisimeme kanye nokuvikeleka kokudla.

Ukusetshenziswa

Ukusetshenziswa okuyinhloko kweThiostrepton kusekwelapheni nasekuvimbeleni ukutheleleka ngamagciwane. Ivimbela ukwakheka kwamaprotheni kumagciwane, ngaleyo ndlela ivimbele ukukhula nokwanda kwawo. Lokhu kuyenza ithuluzi elibalulekile ekulweni nezifo ezahlukahlukene ezibangelwa amagciwane ane-Gram-positive, kusukela ekuthelelekeni kwesikhumba kuya ekuthelelekeni kokuphefumula. Ngaphezu kwalokho, iThiostrepton iphinde yabonakala isebenza kahle ekuthelelekeni okuthile kwesikhunta. Umsebenzi wayo obanzi uyivumela ukuthi ihlasele izinhlobo eziningi zamagciwane amagciwane, okwenza kube yi-antibiotic ehlukahlukene.